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Title: Sitotoksisitas Tanaman Jengger Ayam (Celosia Cristata) Terhadap Sel Kanker Payudara T47D
Authors: Kristiani, Elizabeth Betty Elok
Nugroho, Laurentius Hartanto
Moeljoprawiro, Soekarti
Widyarini, Sitarina
Keywords: C. cristata;T47D cell line;cytotoxicity activity;IC50 Value
Issue Date: Jun-2015
Publisher: Fakultas Pertanian dan Bisnis Universitas Kristen Satya Wacana
Abstract: Breast cancer is a kind of cancer which proven to be the second biggest cause of death after colon cancer. The various side effects of this cancer’s cure right now is stimulating the search of alternative cancer cure through ethnobotanical bioprospecting approach. Celosia cristata is a plant which has high activity of pharmacology but anticancer activity is not yet to be researched. This research was aimed to discover anticancer potential of jengger ayam (C. cristata) through its cytotoxic activity towards T47D breast cancer cell.The root, stem, leaf, and flower of the plant was extracted with maceration. Cytotoxicity test of the extract was using MTT method and the calculation of IC5 extract/fraction was using SPSS (Probit/Logit). The value of IC50 was analyzed with statistics, using analysis of Variance (ANOVA). If there’s a real difference between treatment and control, the test was followed by Tukey test in 5% stage test. BtK and BgK extract showed high citotoxicity towards T47D breast cancer cell in 500 and 250 µg/ml extract concentration. BtK extract with 144,0 µg/ml value of IC50 was the most toxic extract significantly towards T47D cell
Description: Prosiding Konser Karya Ilmiah Nasional 2015, p. 81-86
ISSN: 24605506
Appears in Collections:Prosiding Konser Karya Ilmiah Nasional 2015

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